Motif ID: POU5F1_SOX2{dimer}.p2

Z-value: 1.773


Transcription factors associated with POU5F1_SOX2{dimer}.p2:

Gene SymbolEntrez IDGene Name
POU5F1 5460 POU class 5 homeobox 1
SOX2 6657 SRY (sex determining region Y)-box 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
POU5F1chr6_-_312425930.312.5e-01Click!
SOX2chr3_+_182912405-0.117.0e-01Click!


Activity profile for motif POU5F1_SOX2{dimer}.p2.

activity profile for motif POU5F1_SOX2{dimer}.p2


Sorted Z-values histogram for motif POU5F1_SOX2{dimer}.p2

Sorted Z-values for motif POU5F1_SOX2{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU5F1_SOX2{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_+_96592051 3.326 MBNL2
muscleblind-like 2 (Drosophila)
chr7_+_90176647 2.094 NM_012395
CDK14
cyclin-dependent kinase 14
chr20_+_18742369 1.728 NM_178483
C20orf79
chromosome 20 open reading frame 79
chr17_+_3326045 1.506 NM_000049
ASPA
aspartoacylase
chr1_-_150328153 1.451 NM_001008536
TCHHL1
trichohyalin-like 1
chr2_-_45648608 1.438 SRBD1
S1 RNA binding domain 1
chr12_+_102859354 1.375 HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr17_+_57811645 1.343 NM_173503
EFCAB3
EF-hand calcium binding domain 3
chr12_-_66839589 1.319 NM_000619
IFNG
interferon, gamma
chr6_-_66346417 1.298 NM_198283
EYS
eyes shut homolog (Drosophila)
chr2_+_166034402 1.214 NM_001172173
CSRNP3
cysteine-serine-rich nuclear protein 3
chr1_+_93072947 1.172 RPL5
ribosomal protein L5
chr12_-_10846435 1.081 NM_023919
TAS2R7
taste receptor, type 2, member 7
chr10_+_91127792 1.061 NM_001010987
IFIT1B
interferon-induced protein with tetratricopeptide repeats 1B
chr1_+_245835478 1.055 NM_001001914
OR2G3
olfactory receptor, family 2, subfamily G, member 3
chr4_-_151993422 1.017


chr14_-_106154332 1.007 LOC100126583
IGHG1
hypothetical LOC100126583
immunoglobulin heavy constant gamma 1 (G1m marker)
chr17_+_24394281 1.000 PIPOX
pipecolic acid oxidase
chr9_+_6205804 0.976 IL33
interleukin 33
chrX_+_135397790 0.944 NM_001727
BRS3
bombesin-like receptor 3
chr9_-_21340885 0.936 NM_021002
IFNA6
interferon, alpha 6
chr9_-_21197141 0.931 NM_002171
IFNA10
interferon, alpha 10
chr15_-_81271859 0.905 NM_001007122
FSD2
fibronectin type III and SPRY domain containing 2
chr9_+_2707525 0.903 NM_133497
KCNV2
potassium channel, subfamily V, member 2
chr4_-_70861301 0.901 NM_001891
CSN2
casein beta
chr21_+_41663853 0.890 MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr3_+_99484421 0.870 NM_001005482
OR5H2
olfactory receptor, family 5, subfamily H, member 2
chr9_-_21229975 0.865 NM_002172
IFNA14
interferon, alpha 14
chr9_-_4142182 0.862 NM_152629
GLIS3
GLIS family zinc finger 3
chr2_+_165858586 0.859 NM_021007
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr10_-_5436781 0.854 NM_001171864
NM_024803
TUBAL3

tubulin, alpha-like 3

chr17_+_24394043 0.842 NM_016518
PIPOX
pipecolic acid oxidase
chr11_+_111551417 0.842 NM_031938
BCO2
beta-carotene oxygenase 2
chr11_+_110631916 0.821 NM_198498
C11orf53
chromosome 11 open reading frame 53
chr12_+_49634048 0.821 NM_001109619
HIGD1C
HIG1 hypoxia inducible domain family, member 1C
chr15_+_19883745 0.818 NM_001005241
OR4N4
olfactory receptor, family 4, subfamily N, member 4
chr2_-_219614481 0.809 NM_152389
NM_194302
CCDC108

coiled-coil domain containing 108

chr20_-_31055892 0.796 NM_080675
SUN5
Sad1 and UNC84 domain containing 5
chr2_+_138438277 0.790 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr6_-_76838944 0.767 NM_001563
IMPG1
interphotoreceptor matrix proteoglycan 1
chr9_-_74757735 0.765 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr5_+_27508139 0.759 LOC643401
hypothetical protein LOC643401
chr5_-_64813459 0.755 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr12_-_9123126 0.745 A2M
alpha-2-macroglobulin
chrX_+_135210787 0.738 NM_153834
GPR112
G protein-coupled receptor 112
chr7_+_37689903 0.733


chr2_+_113479919 0.730 NM_014440
IL1F6
interleukin 1 family, member 6 (epsilon)
chr9_-_28709302 0.723 NM_152570
LINGO2
leucine rich repeat and Ig domain containing 2
chr15_+_38296920 0.721 NM_001128628
NM_001128629
PAK6

p21 protein (Cdc42/Rac)-activated kinase 6

chr5_+_140751666 0.710 NM_014004
NM_032088
PCDHGA8

protocadherin gamma subfamily A, 8

chr10_+_77212524 0.707 NM_032024
C10orf11
chromosome 10 open reading frame 11
chr5_+_76150637 0.689 F2RL1
coagulation factor II (thrombin) receptor-like 1
chrX_-_55037235 0.684 NM_002625
PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr10_-_27097782 0.682 ABI1
abl-interactor 1
chr14_+_38772870 0.680 NM_054024
MIA2
melanoma inhibitory activity 2
chr11_+_60280915 0.672 NM_001098835
NM_152717
MS4A15

membrane-spanning 4-domains, subfamily A, member 15

chr2_+_207115060 0.670 ADAM23
ADAM metallopeptidase domain 23
chr6_-_22410993 0.669 NM_001163558
PRL
prolactin
chr1_-_93172119 0.656


chr5_+_140552087 0.652 NM_018930
PCDHB10
protocadherin beta 10
chr12_+_7755316 0.647 NM_199286
DPPA3
STELLAR
developmental pluripotency associated 3
developmental pluripotency associated 3 pseudogene
chr11_-_121492010 0.629 NM_001001786
BLID
BH3-like motif containing, cell death inducer
chr3_-_156904690 0.627 NM_014996
PLCH1
phospholipase C, eta 1
chr4_+_100651183 0.625 NM_032149
C4orf17
chromosome 4 open reading frame 17
chr3_+_122794859 0.624 NM_016298
FBXO40
F-box protein 40
chr10_+_124141808 0.618 NM_021622
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr10_-_74863303 0.616 NM_001024593
ZMYND17
zinc finger, MYND-type containing 17
chr20_-_9767406 0.615 NM_020341
NM_177990
PAK7

p21 protein (Cdc42/Rac)-activated kinase 7

chr6_-_52060327 0.614 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr15_+_22619886 0.595 NM_022806
NM_022807
NM_022808
SNRPN


small nuclear ribonucleoprotein polypeptide N


chr3_-_87408301 0.587 NM_000306
NM_001122757
POU1F1

POU class 1 homeobox 1

chr17_+_3324096 0.586 NM_001128085
ASPA
aspartoacylase
chr2_-_138762909 0.584


chr5_-_58331515 0.583 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr1_+_43063817 0.581 NM_018538
ERMAP
erythroblast membrane-associated protein (Scianna blood group)
chr19_+_7734034 0.577 NM_001144904
NM_001144905
NM_001144906
NM_001144907
NM_001144908
NM_001144909
NM_001144910
NM_001144911
NM_014257
CLEC4M








C-type lectin domain family 4, member M








chr15_+_22652790 0.575 NM_022805
SNRPN
small nuclear ribonucleoprotein polypeptide N
chrX_-_138875342 0.573 NM_001013403
CXorf66
chromosome X open reading frame 66
chr2_+_68445821 0.572 NM_002664
PLEK
pleckstrin
chr4_+_70928718 0.572 NM_000200
HTN3
histatin 3
chr3_-_150422474 0.571 NM_000096
CP
ceruloplasmin (ferroxidase)
chr2_-_200038055 0.567 NM_001172517
SATB2
SATB homeobox 2
chr17_-_43254132 0.563 NM_145798
OSBPL7
oxysterol binding protein-like 7
chr3_+_99334230 0.560 NM_001005338
OR5H1
olfactory receptor, family 5, subfamily H, member 1
chr6_-_108252200 0.551 NM_198081
SCML4
sex comb on midleg-like 4 (Drosophila)
chr5_+_140235114 0.548 NM_018903
NM_031864
PCDHA12

protocadherin alpha 12

chr6_+_26153590 0.547 NM_003531
HIST1H3C
histone cluster 1, H3c
chr13_+_22653059 0.543 NM_000231
SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chr16_+_70646008 0.540 NM_001126102
NM_005143
HP

haptoglobin

chr18_+_74957475 0.534


chr3_-_106903734 0.534 CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr1_-_41398126 0.531 NM_001172222
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr5_+_140532385 0.528 NM_018940
PCDHB7
protocadherin beta 7
chr5_+_140719773 0.522 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr18_-_73834670 0.521


chr17_-_43254117 0.519 OSBPL7
oxysterol binding protein-like 7
chr11_-_35398077 0.516 NM_001195728
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr10_+_96512447 0.514 NM_000769
CYP2C19
cytochrome P450, family 2, subfamily C, polypeptide 19
chr7_+_129057152 0.514 NM_001040110
NRF1
nuclear respiratory factor 1
chr6_-_43384507 0.513 NM_206922
CRIP3
cysteine-rich protein 3
chr6_+_123142559 0.510 FABP7
fatty acid binding protein 7, brain
chr4_+_113437947 0.509 NM_001102406
NM_025144
ALPK1

alpha-kinase 1

chr3_+_28406990 0.507 NM_001040432
ZCWPW2
zinc finger, CW type with PWWP domain 2
chr12_-_90097384 0.505 NM_133503
DCN
decorin
chr7_+_29486010 0.505 NM_001039936
CHN2
chimerin (chimaerin) 2
chr7_-_36730525 0.502 NM_001177506
NM_001177507
NM_001637
AOAH


acyloxyacyl hydrolase (neutrophil)


chr5_+_76150588 0.498 NM_005242
F2RL1
coagulation factor II (thrombin) receptor-like 1
chr1_+_69998445 0.489 NM_020794
LRRC7
leucine rich repeat containing 7
chr2_-_233349469 0.483 NM_001172416
NM_001172417
NM_002242
KCNJ13


potassium inwardly-rectifying channel, subfamily J, member 13


chr14_-_106330781 0.479 IGHV5-78
immunoglobulin heavy variable 5-78 pseudogene
chr1_+_156842852 0.479 NM_001004478
OR10Z1
olfactory receptor, family 10, subfamily Z, member 1
chr4_-_21155376 0.475 NM_001035004
KCNIP4
Kv channel interacting protein 4
chr1_-_150148608 0.472 NM_053055
THEM4
thioesterase superfamily member 4
chr13_-_109600709 0.471 COL4A1
collagen, type IV, alpha 1
chr6_+_64344307 0.468 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr11_-_128242342 0.466 NM_153764
NM_153765
NM_153766
NM_153767
KCNJ1



potassium inwardly-rectifying channel, subfamily J, member 1



chr9_-_99740243 0.466 NM_197978
HEMGN
hemogen
chr1_-_100003936 0.466 NM_001013660
FRRS1
ferric-chelate reductase 1
chr20_+_16312 0.465 NM_153325
DEFB125
defensin, beta 125
chr2_+_191009265 0.464 MFSD6
major facilitator superfamily domain containing 6
chr15_+_63124760 0.463 NM_178859
OSTBETA
organic solute transporter beta
chr7_-_16811131 0.458 NM_006408
AGR2
anterior gradient homolog 2 (Xenopus laevis)
chr5_+_173405343 0.456 HMP19
HMP19 protein
chr6_+_32515596 0.451 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr7_-_84589182 0.449 NM_152754
SEMA3D
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr9_+_104797413 0.448 NM_001340
CYLC2
cylicin, basic protein of sperm head cytoskeleton 2
chr2_-_165768798 0.448 NM_001081676
NM_001081677
NM_006922
SCN3A


sodium channel, voltage-gated, type III, alpha subunit


chr5_+_173405298 0.444 NM_015980
HMP19
HMP19 protein
chr7_-_122422989 0.438 NM_016945
TAS2R16
taste receptor, type 2, member 16
chr3_+_51837608 0.436 NM_001085479
IQCF3
IQ motif containing F3
chr5_-_24535386 0.434 NM_001190450
CDH10
cadherin 10, type 2 (T2-cadherin)
chr13_-_27441143 0.433 CDX2
caudal type homeobox 2
chr9_-_36365965 0.433 RNF38
ring finger protein 38
chr21_-_30583702 0.429 NM_001128598
KRTAP25-1
keratin associated protein 25-1
chr12_-_119733062 0.427 SPPL3
signal peptide peptidase 3
chr7_+_89681069 0.424 NM_001040666
STEAP2
six transmembrane epithelial antigen of the prostate 2
chr11_-_57964221 0.423 NM_001004733
OR5B12
olfactory receptor, family 5, subfamily B, member 12
chr3_-_38810504 0.420 NM_006514
SCN10A
sodium channel, voltage-gated, type X, alpha subunit
chr1_+_168381811 0.419 NM_001136107
METTL11B
methyltransferase like 11B
chr18_+_59571256 0.415 NM_001040147
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr6_-_88917600 0.412 NM_001160260
CNR1
cannabinoid receptor 1 (brain)
chr10_+_95838801 0.410 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr12_+_103221590 0.408 NM_001008394
EID3
EP300 interacting inhibitor of differentiation 3
chr6_-_167491305 0.408 NM_005299
GPR31
G protein-coupled receptor 31
chr11_-_62508946 0.407 NM_004790
NM_153276
NM_153277
NM_153278
SLC22A6



solute carrier family 22 (organic anion transporter), member 6



chr11_-_59390518 0.407 NM_001062
TCN1
transcobalamin I (vitamin B12 binding protein, R binder family)
chrX_+_79562601 0.405 NM_152630
FAM46D
family with sequence similarity 46, member D
chr3_+_133798770 0.405 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr10_-_32707549 0.404 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr14_-_106149623 0.404


chr5_-_43448174 0.404 NM_148672
CCL28
chemokine (C-C motif) ligand 28
chr5_+_140227951 0.404 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr3_-_153541468 0.400 NM_001123228
TMEM14E
transmembrane protein 14E
chr6_-_119512035 0.400 NM_001100411
FAM184A
family with sequence similarity 184, member A
chr5_+_140541163 0.399 NM_020957
PCDHB16
protocadherin beta 16
chr8_-_11891168 0.393 NM_001033019
DEFB134
defensin, beta 134
chr12_+_54106304 0.393 NM_001005183
OR6C76
olfactory receptor, family 6, subfamily C, member 76
chr2_-_171631728 0.392 NM_001136555
TLK1
tousled-like kinase 1
chr1_+_57093030 0.389 NM_000562
C8A
complement component 8, alpha polypeptide
chr1_-_229071957 0.384 NM_001136494
C1orf198
chromosome 1 open reading frame 198
chr4_+_70831387 0.381 NM_001025104
NM_001890
CSN1S1

casein alpha s1

chr10_-_116408046 0.378 NM_002313
ABLIM1
actin binding LIM protein 1
chr11_+_59804634 0.378 NM_148975
MS4A4A
membrane-spanning 4-domains, subfamily A, member 4
chr4_+_185063421 0.377 NM_020225
STOX2
storkhead box 2
chr5_-_135318420 0.376 NM_002302
LECT2
leukocyte cell-derived chemotaxin 2
chr5_+_140241976 0.375 NM_018904
NM_031865
PCDHA13

protocadherin alpha 13

chr1_-_151296611 0.374 NM_005988
SPRR2A
small proline-rich protein 2A
chr11_+_82078217 0.374


chr5_+_79366746 0.374 NM_003248
THBS4
thrombospondin 4
chr19_-_62370667 0.373 NM_001012729
DUXA
double homeobox A
chr13_+_75092570 0.371 NM_005358
LMO7
LIM domain 7
chr18_+_61568825 0.365 CDH7
cadherin 7, type 2
chr14_-_76958984 0.365 NM_138791
NM_001113475
C14orf148

chromosome 14 open reading frame 148

chr11_-_9182356 0.363 DENND5A
DENN/MADD domain containing 5A
chr12_-_69600514 0.363 PTPRR
protein tyrosine phosphatase, receptor type, R
chr14_+_87560646 0.362 LOC283587
hypothetical protein LOC283587
chr14_+_38720085 0.360 PNN
pinin, desmosome associated protein
chr6_-_50045296 0.360 NM_001037729
DEFB113
defensin, beta 113
chrX_+_70255128 0.360 NM_005120
MED12
mediator complex subunit 12
chr14_+_31868229 0.359 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr8_-_120720200 0.356 NM_001040092
NM_001130863
NM_006209
ENPP2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr12_-_14887648 0.356 NM_021071
ART4
ADP-ribosyltransferase 4 (Dombrock blood group)
chr10_-_98109048 0.353 NM_001040102
NM_001040103
NM_033207
OPALIN


oligodendrocytic myelin paranodal and inner loop protein


chr21_-_35174742 0.353 RUNX1
runt-related transcription factor 1
chr9_-_21192201 0.348 NM_021057
IFNA7
interferon, alpha 7
chr21_-_30884586 0.347 NM_001164434
KRTAP22-2
keratin associated protein 22-2
chr4_+_120276386 0.346 NM_016599
MYOZ2
myozenin 2
chr6_+_131190237 0.345 NM_001195597
LOC285733
hypothetical LOC285733
chr12_+_7833292 0.343 NANOG
Nanog homeobox
chr3_+_2908920 0.342 NM_175613
CNTN4
contactin 4
chr7_-_122126422 0.340 NM_139175
RNF133
ring finger protein 133
chr9_+_21399132 0.339 NM_002170
IFNA8
interferon, alpha 8
chr2_+_211166323 0.339 NM_001122634
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr4_+_77575276 0.337 NM_020859
SHROOM3
shroom family member 3
chr8_-_7710547 0.336 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chr8_+_42671718 0.335 NM_000749
CHRNB3
cholinergic receptor, nicotinic, beta 3
chr6_+_132000134 0.335 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr8_+_32905027 0.334


chr4_-_152368492 0.334 SH3D19
SH3 domain containing 19
chr17_+_18700385 0.332 PRPSAP2
phosphoribosyl pyrophosphate synthetase-associated protein 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.92 5.15e-10 GO:0007606 sensory perception of chemical stimulus
2.98 2.79e-09 GO:0007608 sensory perception of smell
1.33 1.77e-07 GO:0050896 response to stimulus
2.16 7.65e-07 GO:0007600 sensory perception
2.21 1.07e-06 GO:0006955 immune response
1.99 1.24e-04 GO:0006952 defense response
1.72 2.22e-04 GO:0050877 neurological system process
1.29 1.06e-03 GO:0032501 multicellular organismal process
1.58 1.67e-03 GO:0003008 system process
1.67 3.79e-03 GO:0002376 immune system process
2.24 5.45e-03 GO:0051707 response to other organism
2.27 1.04e-02 GO:0045087 innate immune response
2.03 2.05e-02 GO:0009607 response to biotic stimulus
4.34 2.92e-02 GO:0001959 regulation of cytokine-mediated signaling pathway
4.34 2.92e-02 GO:0060337 type I interferon-mediated signaling pathway
4.34 2.92e-02 GO:0071357 cellular response to type I interferon
4.27 3.46e-02 GO:0034340 response to type I interferon
4.27 3.46e-02 GO:0060759 regulation of response to cytokine stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.44 1.72e-08 GO:0005886 plasma membrane
1.43 4.54e-08 GO:0071944 cell periphery
1.65 1.93e-07 GO:0005576 extracellular region
1.72 6.63e-04 GO:0044421 extracellular region part
1.76 4.62e-03 GO:0005615 extracellular space
1.22 1.08e-02 GO:0031224 intrinsic to membrane
1.22 1.69e-02 GO:0016021 integral to membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.84 2.58e-12 GO:0004871 signal transducer activity
1.84 2.58e-12 GO:0060089 molecular transducer activity
2.12 3.65e-12 GO:0004888 transmembrane receptor activity
1.91 2.94e-11 GO:0004872 receptor activity
3.06 3.53e-10 GO:0004984 olfactory receptor activity
2.28 1.42e-09 GO:0004930 G-protein coupled receptor activity
1.89 2.48e-03 GO:0005509 calcium ion binding
2.48 3.42e-02 GO:0005125 cytokine activity